Intrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons

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Intrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons

Neurons in the midline and intralaminar thalamic nuclei are components of an interconnected brainstem, limbic and prefrontal cortex neural network that is engaged during arousal, vigilance, motivated and addictive behaviors, and stress. To better understand the cellular mechanisms underlying these functions, here we review some of the recently characterized electrophysiological and neuropharmac...

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Properties of a T-type Ca2+channel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons.

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Title: Properties of a T-type Cachannel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons

Burst firing mediated by the low threshold spike (LTS) is a hallmark of many thalamic neurons. However, post-burst afterhyperpolarizations (AHPs) are relatively uncommon in thalamus. We now report data from patch-clamp recordings in rat brain slice preparations that reveal an LTSinduced slow AHP (sAHP) in thalamic paraventricular (PVT) and other midline neurons, but not in ventrobasal or reticu...

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Properties of a T-Type Ca Channel–Activated Slow Afterhyperpolarization in Thalamic Paraventricular Nucleus and Other Thalamic Midline Neurons

Zhang L, Renaud LP, Kolaj M. Properties of a T-type Ca channel– activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons. J Neurophysiol 101: 2741–2750, 2009. First published March 25, 2009; doi:10.1152/jn.91183.2008. Burst firing mediated by a low-threshold spike (LTS) is the hallmark of many thalamic neurons. However, postburst afterhyperpol...

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Midline thalamic paraventricular nucleus neurons display diurnal variation in resting membrane potentials, conductances, and firing patterns in vitro.

Neurons in the rodent midline thalamic paraventricular nucleus (PVT) receive inputs from brain stem and hypothalamic sites known to participate in sleep-wake and circadian rhythms. To evaluate possible diurnal changes in their excitability, we used patch-clamp techniques to record and examine the properties of neurons in anterior PVT (aPVT) in coronal rat brain slices prepared at zeitgeber time...

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ژورنال

عنوان ژورنال: Frontiers in Behavioral Neuroscience

سال: 2014

ISSN: 1662-5153

DOI: 10.3389/fnbeh.2014.00132